Qhov xav tau kev kho mob
COVID-19 yog tshwm sim los ntawm kev kis tus kab mob tshiab SARS-CoV-2 tus kab mob, uas koom nrog thiab nkag mus rau hauv cov hlwb los ntawm nws cov protein ntau.Tam sim no, muaj ntau dua 138.3 lab cov ntaub ntawv sau tseg thoob ntiaj teb, nrog cov neeg tuag ze li peb lab.
Txawm hais tias cov tshuaj tiv thaiv tau pom zoo siv thaum muaj xwm txheej ceev, lawv qhov kev ua tau zoo ntawm qee qhov kev hloov pauv tshiab tau raug nug.Tsis tas li ntawd, kev txhaj tshuaj tiv thaiv tsawg kawg yog 70% ntawm cov pej xeem hauv txhua lub tebchaws hauv ntiaj teb yuav siv sijhawm ntev, xav txog qhov kev txhaj tshuaj tiv thaiv tam sim no, kev tsis txaus ntawm kev tsim tshuaj tiv thaiv, thiab kev sib tw logistical.
Lub ntiaj teb tseem yuav xav tau cov tshuaj siv tau zoo thiab nyab xeeb, yog li ntawd, txhawm rau cuam tshuam rau cov mob hnyav tshwm sim los ntawm tus kab mob no.Kev tshuaj xyuas tam sim no tsom rau tus kheej thiab kev ua haujlwm sib koom ua ke ntawm curcumin thiab nanostructures tiv thaiv tus kab mob.

Qhov xav tau kev kho mob
COVID-19 yog tshwm sim los ntawm kev kis tus kab mob tshiab SARS-CoV-2 tus kab mob, uas koom nrog thiab nkag mus rau hauv cov hlwb los ntawm nws cov protein ntau.Tam sim no, muaj ntau dua 138.3 lab cov ntaub ntawv sau tseg thoob ntiaj teb, nrog cov neeg tuag ze li peb lab.
Txawm hais tias cov tshuaj tiv thaiv tau pom zoo siv thaum muaj xwm txheej ceev, lawv qhov kev ua tau zoo ntawm qee qhov kev hloov pauv tshiab tau raug nug.Tsis tas li ntawd, kev txhaj tshuaj tiv thaiv tsawg kawg yog 70% ntawm cov pej xeem hauv txhua lub tebchaws hauv ntiaj teb yuav siv sijhawm ntev, xav txog qhov kev txhaj tshuaj tiv thaiv tam sim no, kev tsis txaus ntawm kev tsim tshuaj tiv thaiv, thiab kev sib tw logistical.
Lub ntiaj teb tseem yuav xav tau cov tshuaj siv tau zoo thiab nyab xeeb, yog li ntawd, txhawm rau cuam tshuam rau cov mob hnyav tshwm sim los ntawm tus kab mob no.Kev tshuaj xyuas tam sim no tsom rau tus kheej thiab kev ua haujlwm sib koom ua ke ntawm curcumin thiab nanostructures tiv thaiv tus kab mob.

Curcumin
Curcumin yog ib qho polyphenolic compound cais los ntawm rhizome ntawm cov nroj tsuag turmeric, Curcuma longa.Nws ua rau cov curcuminoid loj hauv cov nroj tsuag no, ntawm 77% ntawm tag nrho, thaum cov khoom me me curcumin II ua rau 17%, thiab curcumin III muaj 3%.
Curcumin tau raug tus cwj pwm thiab kawm kom ntxaws, raws li lub ntuj molecule nrog cov khoom siv tshuaj.Nws txoj kev kam rau siab thiab kev nyab xeeb tau raug sau tseg zoo, nrog rau qhov siab tshaj plaws ntawm 12 g / hnub.
Nws siv tau piav raws li kev tiv thaiv kab mob, tshuaj tiv thaiv kab mob, thiab tshuaj tua kab mob, nrog rau tshuaj tua kab mob.Curcumin tau raug qhia tias yog ib qho molecule nrog lub peev xwm los kho pulmonary edema thiab lwm yam kev raug mob uas ua rau lub ntsws fibrosis tom qab COVID-19.

Curcumin inhibits cov kab mob enzymes
Qhov no tau xav tias yog vim nws lub peev xwm los cuam tshuam tus kab mob nws tus kheej, nrog rau kev hloov kho txoj hauv kev.Nws tswj hwm tus kab mob kis kab mob thiab kev tswj hwm, khi nrog lub zog siab rau cov kab mob tseem ceeb protease (Mpro) enzyme uas yog tus yuam sij rau kev rov ua dua tshiab thiab inhibits kab mob txuas thiab nkag mus rau hauv lub xov tooj ntawm tes.Nws kuj tseem tuaj yeem cuam tshuam cov kab mob.
Nws cov hom phiaj tiv thaiv kab mob muaj xws li kab mob siab C, kab mob tib neeg tiv thaiv kab mob (HIV), kab mob Epstein-Barr thiab kab mob khaub thuas A.Nws tau raug tshaj tawm tias inhibit 3C-zoo li protease (3CLpro) zoo dua li lwm yam khoom ntuj, suav nrog quercetin, lossis tshuaj xws li chloroquine thiab hydroxychloroquine.
Qhov no tuaj yeem ua rau txo qis ntawm cov kab mob hauv tib neeg lub cell sai dua li lwm cov tshuaj tiv thaiv tsawg dua, thiab yog li tiv thaiv kev kis kab mob mus rau qhov mob ua pa nyuaj (ARDS).
Nws kuj tseem inhibits papain-zoo li protease (PLpro) nrog 50% inhibitory concentration (IC50) ntawm 5.7 µM uas tshaj quercetin thiab lwm yam khoom ntuj.

Curcumin inhibits host cell receptor
Tus kab mob no txuas rau tib neeg lub hom phiaj cell receptor, angiotensin-hloov enzyme 2 (ACE2).Cov qauv kev tshawb fawb tau pom tias curcumin inhibits tus kab mob no-receptor kev sib cuam tshuam hauv ob txoj hauv kev, los ntawm inhibiting ob qho tib si spike protein thiab ACE2 receptor.
Txawm li cas los xij, curcumin muaj bioavailability tsawg, vim tias nws tsis yaj zoo hauv dej thiab tsis ruaj khov hauv cov xov xwm aqueous, tshwj xeeb tshaj yog pH siab dua.Thaum noj tshuaj, nws nkag mus rau cov metabolism hauv lub plab thiab lub siab sai.Qhov teeb meem no tuaj yeem kov yeej los ntawm kev siv nanosystems.
Muaj ntau yam sib txawv nanostructured nqa khoom siv rau lub hom phiaj no, xws li nanoemulsions, microemulsions, nanogels, micelles, nanoparticles thiab liposomes.Cov neeg nqa khoom zoo li no tiv thaiv cov metabolism hauv kev puas tsuaj ntawm curcumin, nce nws cov solubility thiab pab nws txav mus los ntawm cov kab mob lom.
Peb lossis ntau dua nanostructure-based curcumin cov khoom lag luam twb muaj muag, tab sis ob peb txoj kev tshawb fawb tau tshuaj xyuas lawv cov txiaj ntsig tiv thaiv COVID-19 hauv vivo.Cov no tau qhia txog lub peev xwm ntawm cov qauv tsim los hloov kho lub cev tiv thaiv kab mob thiab txo cov tsos mob ntawm tus kab mob, thiab tej zaum yuav maj mam rov qab los.